Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 23rd International Conference on Advanced Materials & Nanotechnology Tokyo, Japan.

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Scientific Program Day 1

Day 1 :

Keynote Forum

Amany A Mostafa

National Research Center, Egypt

Keynote: Sustained drug release scaffolds as bone implants

Time : 09:05-10:05 AM

Conference Series Advanced Materials-Japan-2019 International Conference Keynote Speaker Amany A Mostafa photo
Biography:

Professor Amany Mostafa has completed her PhD from Cairo University and postdoctoral studies from GeorgiaTech University, Petite Parker Institute for Bioscience & Bioengineering. She is currently the Head of Inorganic Chemical Industries & Mineral Resources Division at the National Research Centre, Egypt. She manged many International Projects. Her research interests are focused on Materials Science and Nanotechnology and their applications in industry as well as the medical research area. Her expertise has been developed as part of a long standing interdisciplinary collaborative work in nanomaterials used for Regenerative Medicine: Biomaterials, Drug delivery and Tissue engineering.

Abstract:

The current work presents the fabrication of newly designed scaffolds from mixture of chitosan (CS) / polyvinyl alcohol (PVA) and bioactive glass (CS/PVA-G) loaded with an antiosteoporotic drug; risedronate sodium for bone regeneration. The scaffolds were formulated using Freeze drying technique utilizing a mixture of two types of polymers. The prepared scaffolds were then characterized regarding their porosity and the in-vitro drug release pattern. The selected bioactive glasses and the scaffolds were subjected for an in vitro cell evaluation and in vivo experimental animal studies either in rats or in dogs. The results showed that the particle size of the prepared nanobioactive glass by modified sol-gel technique ranging between 5.9-13.7 nm. The prepared scaffolds show that the presence of CS and BG resulted in higher porosity while the addition of drug lowered the porosity percent. The in vitro release study proves the sustained drug release profile of the tested scaffolds up to two months. Tensile testing of the selected scaffolds showed that adding 10% BG resulted in scaffolds of higher strength and stiffness compared to 30%BG. In vitro cell tests of the scaffolds reveal higher proliferation level of the Saos-2 cells on medicated formulations than their counter part formulations without risedronate. In vivo post-operative radiographs in critical-sized mandibular bone defect in dogs revealed induced bone after 10 weeks. Therefore, the CS/PVA-G scaffolds are safe and useful materials against osteoporosis and could be used for bone regeneration.

Keynote Forum

Tsu-Hsun Hou

National Sun Yat-Sen University, Taiwan

Keynote: The unit cell prediction of two-dimensional supramolecule by STUN-BH-DMD method and molecular dynamics simulation

Time : 11:15-11:45

Conference Series Advanced Materials-Japan-2019 International Conference Keynote Speaker Tsu-Hsun Hou photo
Biography:

Tsu-Hsun Hou is currently pursuing Master's degree at National Sun Yat-sen University in Kaohsiung, Taiwan. In recent years, he has been particularly engaged in the research of metal high-entropy alloys, biomolecules, polymers, supramolecules and so on. He has also worked with a number of medical research institutions and through both the experimental and the analog end of the collaboration, research efficiency can be greatly improved.

Abstract:

The unit cell of two-dimensional STA supramolecule on a virtual graphene surface was predicted in this study. The DRIEDING force field was used to describe the interatomic interactions and the Electrostatic Surface Potential (ESP) charges obtained by the semi-empirical ab initio package VAMP with the NDDO (Neglect of Diatomic Differential Overlap) Hamiltonians approximation method of PM6 (Parameterization Method 6) was used for the DREIDING potential. First, the Stochastic Tunneling-Basin-Hopping-Discrete molecular dynamics method (STUN-BH-DMD) was used to predict the most stable STA layer on the virtual graphene surface. The box shape was adjusted during the STUN-BH-DMD search process and
the ordered unit cell of STA supramolecule was predicted. The molecular dynamics simulations were used to investigate the
thermal stability and diffusion behaviors of STA supramolecule. The energy-temperature profiles were used to pinpoint the temperatures, at which the STA supramolecule structure begins damaged and the mean-square displacement profiles were used to investigate the dynamical behaviors of STA supramolecules at different temperatures as well as deriving the diffusion
coefficients of STA.

Keynote Forum

Kai-Chi Chang

National Sun Yat-sen University, Taiwan

Keynote: Prediction of mechanical, thermodynamic and chemical properties of Al-Nb-Ta-Ti-Zr-Mo highentropy alloys by simulation process

Time : 12:15-12:45

Conference Series Advanced Materials-Japan-2019 International Conference Keynote Speaker Kai-Chi Chang photo
Biography:

Kai-Chi Chang is currently pursuing Master's degree at National Sun Yat-sen University in Kaohsiung, Taiwan. In recent years, he has been particularly engaged in the research of metal high-entropy alloys, biomolecules, polymers, supramolecules and so on. He has also worked with a number of medical research institutions and through both the experimental and the analog end of the collaboration, research efficiency can be greatly improved.

Abstract:

This study has developed a complete simulation procedure for designing new High Entropy Alloy (HEA) by combining
Density Functional Theory (DFT), Particle Swarm Optimization (PSO), Basin-Hopping (BH) method and Molecular
Dynamics (MD) simulation. The second-Nearest Neighbor Modified Embedded-Atom Method (2NN MEAM) potential
with the parameters fitted by PSO is used for BH and MD methods. By this procedure, the most stable HEA structures at
different element compositions can be predicted. By using the advantages of MD simulations, the detailed HEA structures and
their mechanical properties including Young’s moduli, bulk modulus and strengths can be predicted. The tensile simulations
was systematically applied to the HEAs with different element compositions for observing the HEA fracture mechanism and
understanding the relationship between the mechanical properties and the HEA element composition.

Keynote Forum

Tetiana Dudka

Shanghai University, China

Keynote: Tunable Fluorescence Anisotropy Of Lead Halide Perovskite Nanorods By Anion Exchange

Time : 11:15-11:45

Conference Series Advanced Materials-Japan-2019 International Conference Keynote Speaker Tetiana Dudka photo
Biography:

Professor Tetiana Dudka has Department of Materials Science and Engineering, and Centre for Functional Photonics (CFP), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong S.A.R Her research interests are focused on demonstrated that the addition of iodide anion improves the polarized emission even for a cubic structure, which is favorable for LED and LCD applications. Perovskite nanorods with elongated shape are suitable candidates to provide higher fluorescence polarization compared with quantum dots.

 

Abstract:

Emission spectra of CsPbX3 (X – halide anion) perovskite nanocrystals can be tuned by the composition based on different ratio of anions. The anion-exchanged perovskite nanocrystals that can be obtained by substitution of Br- in CsPbBr3 to Cl- or I- have been reported for quantum dots with a goal to tune emission wavelength, manipulate optical bandgap and improve their optoelectronic properties. It was demonstrated that the addition of iodide anion improves the polarized emission even for a cubic structure, which is favorable for LED and LCD applications. However, the achieved fluorescence anisotropy was not high enough and thus remains a challenge for perovskite nanomaterials. Perovskite nanorods with elongated shape are suitable candidates to provide higher fluorescence polarization compared with quantum dots. We realized a direct synthesis of CsPbBr3 nanorods via the crystal phase transformation, and, by conducting partial anion exchange from Br- to I-), we demonstrate enhancement of the fluorescence anisotropy of mixed-anion CsPbBr3-xIx  nanorods from 0.02 to impressive values of 0.1-0.35. The reason for an improved fluorescence polarization of perovskite nanorods is due to the distortion of the original orthorhombic phase of CsPbBr3 by larger size iodine anions, which breaks the space inversion symmetry of the structure. Regarding bonding electrons as anisotropic harmonic oscillators, the introduction of iodine atoms make the whole structure more ionic and aligns those oscillators in one direction, thus enhancing the fluorescence polarization. 

 

 

Keynote Forum

Yu-Sheng Lin

National Sun Yat-Sen University, Taiwan

Keynote: Predicting the most stable EpB/target molecule complex by stochastic tunneling-basin Hopping- Discrete Molecular Dynamics method

Time : 12:15-12:45

Conference Series Advanced Materials-Japan-2019 International Conference Keynote Speaker Yu-Sheng Lin photo
Biography:

Yu Sheng Lin is currently pursuing Master’s degree from National Sun Yat-sen University in Taiwan. He has focused on the molecular dynamics simulation during his period of study, mainly analyzing the structure types of molecular adsorption between the aptamer and target molecules.

Abstract:

The global minimum search method (STUN-BH-DMD method for abbreviation) combining the strengths of the Stochastic
Tunneling, Basin Hopping and Discrete Molecular Dynamics method was used to predict the most stable AptEpB/EpCAM
complex. The epithelial cell adhesion molecule (EpCAM, PDB code: 4MZV) was used as a target molecule for the EpCAM
aptamer EpA (AptEpB). For the most stable AptEpB/EpCAM complex predicted by the STUN-BH-DMD method, the AptEpB
is attached to the entangling loop fragments of two EpCAM molecules with most AptEpB residues. After the AptEpB/EpCAM
complex equilibrated with the water environment by the MD simulation at 300 K for 10 ns, the stable hydrogen bonds formed
between the bases of AptEpB and EpCAM residues of the secondary structures including the alpha helix and beta sheet become
less stable in the water environment.

Keynote Forum

Qiaoli Yang

Huazhong University of Science and Technology, China

Keynote: Fluorescent carbon dots based ratiometric pH sensor for direct detection of Escherichia coli O157:H7

Time : 11:15-11:45

Conference Series Advanced Materials-Japan-2019 International Conference Keynote Speaker Qiaoli Yang photo
Biography:

Qiaoli Yang is currently a PhD candidate at the Department of Biomedical Engineering, Huazhong University of Science and Technology, under supervision of Professor Shenqi Wang. Her research interests include the development of nanocomposite and construction of bacteriophage based sensors for sensitive and selective detection of bacteria.

Abstract:

For sensitive detection of E. coli O157:H7, we report a one-step synthesis of highly water-soluble, biocompatible, fluorescent
and pH-sensitive Carbon Dots (CDs) and their practical application in constructing ratiometric pH sensor. We developed
a simple and easy way to synthesize hydrophilic CDs by the controlled carbonization of sucrose with the help of sulfuric
acid. The as-synthesized CDs are emitting bright green luminescent light without any further treatment, such as passivation.
Detailed fluorescence study showed under the excitation of 410 nm and 350 nm, the ratios of fluorescence intensity (Log[IF410/
IF350]) changed linearly in the range of pH 4.9 to 6.9, in Britton-Robison buffer. As, bacterial growth generally reduces the
pH of the growth medium due to the release of acidic metabolites such as lactic acid, acetic acid and CO2, etc. Based on this
principle, taking advantage of exclusive emission property of the synthesized CDs, they were successfully used for sensing E.
coli O157:H7 growth. While calculating fluorescent intensity of mixture, a linear relationship of E. coli concentration with the
fluorescence intensity (Log[IF410/IF350]) of the mixture was observed. The practical applicability of the synthesized CDs based
ratiometric pH sensor was confirmed to detect E. coli O157:H7 even in real samples like milk and lake water. The Limit of
Detection (LOD) was approximately 1 CFU/mL. In conclusion, the synthesis of our hydrophilic, biocompatible, pH sensitive
and fluorescent CDs and their application for detection of E. coli O157:H7 were all artless, rapid, cheap and efficient practices.